Male-to-female transsexualism has sometimes been called "Harry Benjamin's syndrome" after the endocrinologist who pioneered the study of dysphoria. The World Professional Association for Transgender Health WPATH , and many transsexual people, had recommended this removal,  arguing that at least some mental health professionals are being insensitive by labelling transsexualism as a "disease" rather than as an inborn trait as many transsexuals believe it to be. Likewise, studies such as Rametti's have found that trans men have male-like white matter patterns even before using hormones , regardless of sexual orientation. Like other trans people, transsexual people prefer to be referred to by the gender pronouns and terms associated with their gender identity. In such cases, while defining sexual attraction, it is best to focus on the object of their attraction rather than on the sex or gender of the subject. It defined transsexualism as "[a] desire to live and be accepted as a member of the opposite sex, usually accompanied by a sense of discomfort with, or inappropriateness of, one's anatomic sex, and a wish to have surgery and hormonal treatment to make one's body as congruent as possible with one's preferred sex. The term, along with gynephilia, is needed to overcome immense difficulties in characterizing the sexual orientation of transmen and transwomen.
Individuals who have undergone and completed sex reassignment surgery are sometimes referred to as transsexed individuals;  however, the term transsexed is not to be confused with the term transsexual, which can also refer to individuals who have not yet undergone SRS, and whose anatomical sex still does not match their psychological sense of personal gender identity. Gynephilic transsexed woman refers to a woman of transsexual background whose sexual preference is for women. Harry Benjamin said in With regard to genetic factors, a study by Hare reported that trans women have a longer androgen receptor gene than cis men, which is less effective at binding testosterone, potentially preventing complete masculinization of the brain prenatal androgen exposure or sensitivity, or lack thereof, is an often cited mechanism to explain observed brain-structure differences. What would be the situation after corrective surgery has been performed and the sex anatomy now resembles that of a woman? Studies have also found that both androphilic and gynephilic trans women's brain function and responses are like cis women's and unlike cis men's, or are intermediate between the two. For example, a trans man is a person who was assigned the female sex at birth on the basis of his genitals , but despite that assignment, identifies as a man and is transitioning or has transitioned to a male gender role; in the case of a transsexual man, he furthermore has or will have a masculine body. For completeness, a lesbian is a gynephilic woman, a woman who likes other women. For instance, it is difficult to decide whether a transman erotically attracted to males is a heterosexual female or a homosexual male; or a transwoman erotically attracted to females is a heterosexual male or a lesbian female. Is the "new woman" still a homosexual man? It defined transsexualism as "[a] desire to live and be accepted as a member of the opposite sex, usually accompanied by a sense of discomfort with, or inappropriateness of, one's anatomic sex, and a wish to have surgery and hormonal treatment to make one's body as congruent as possible with one's preferred sex. Male-to-female transsexualism has sometimes been called "Harry Benjamin's syndrome" after the endocrinologist who pioneered the study of dysphoria. In , Hirschfeld introduced the German term "Transsexualismus",  after which David Oliver Cauldwell introduced "transsexualism" and "transsexual" to English in and Principle 18 of The Yogyakarta Principles , a document of international human rights law ,  opposes such diagnosis as mental illness as medical abuse. There can be various reasons for this, from the personal to the financial. The term, along with gynephilia, is needed to overcome immense difficulties in characterizing the sexual orientation of transmen and transwomen. In , Hirschfeld supervised the second genital reassignment surgery to be reported in detail in a peer-reviewed journal, that of Lili Elbe of Denmark. True transsexuals feel that they belong to the other sex, they want to be and function as members of the opposite sex, not only to appear as such. Another reason for objecting to the term transsexual is the concern that it implies something to do with sexuality , when it is actually about gender identity. Michael Bailey , and Martin Lalumiere , who she says "have completely failed to appreciate the implications of alternative ways of framing sexual orientation. Alternatively, I use gynephilic and androphilic to refer to sexual preference for women and men, respectively. The most studied factors are biological. The previous version, ICD, had incorporated transsexualism, dual role transvestism, and gender identity disorder of childhood into its gender identity disorder category. Those who are writing and researching in this area would do well to adopt his clear and concise vocabulary. Benjamin gave certifying letters to his MTF transsexual patients that stated "Their anatomical sex, that is to say, the body, is male. Since homosexual, gay, and lesbian are often associated with bigotry and exclusion in many societies, the emphasis on sexual affiliation is both appropriate and socially just. Any attempt to classify them may not only cause confusion but arouse offense among the affected subjects.
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